EZH2-IN-22

• Target:

  Histone Methyltransferase

• Related Pathways:

  Chromatin/Epigenetic

• Bioactivity:

  EZH2-IN-22 (example 92) is a potent EZH2 inhibitor, exhibiting IC50 values of <0.00051 µM for EZH2 (Y641N) and EZH2 (Y641F), and 0.00052 µM for EZH2 (wt) . Additionally, EZH2-IN-22 demonstrates antiproliferative activity.

• Smiles:

  C(=C\C(O)=O)\C(O)=O.N(CC)(C1=C(C)C(C(NCC2=C(C)C=C(C)NC2=O)=O)=CC(O[C@@H]3C[C@H](C3)N4CCCCC4)=C1)C5CCOCC5

• Molecular Formula:

  C36H50N4O8

• Molecular Weight:

  666.8

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2766231-05-2