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AChE/BuChE-IN-1

CAT: 0931-T72763-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T72763-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
84212-49-7
Target
Cholinesterase (ChE), Others
Related Pathways
Others, Neuroscience
Bioactivity
AChE/BuChE-IN-1, a selective butyrylcholinesterase (BuChE) inhibitor derived from chrysin, exhibits a potent efficacy with an IC50 of 0.48 μM against BuChE and a lesser inhibitory effect on acetylcholinesterase (AChE) with an IC50 of 7.16 μM. It demonstrates significant hydroxyl radical (·OH) scavenging activity, achieving an IC50 of 0.1674 μM, and effectively inhibits reactive oxygen species (ROS) and Aβ 1-42 aggregation, including self-aggregation, copper (Cu 2+) -induced, and AChE-induced aggregation. Characterized by high blood-brain barrier (BBB) permeability, bioavailability, and low cellular toxicity, AChE/BuChE-IN-1 holds promising potential for Alzheimer's disease (AD) research.
Smiles
O=C1C=2C(OC(=C1)C3=CC=CC=C3)=CC(OCCN(C)C)=CC2O
Molecular Formula
C19H19NO4
Molecular Weight
325.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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