Umbralisib sulfate

• Target:

  Casein Kinase|||Others|||PI3K

• Related Pathways:

  Others|||Metabolism|||PI3K/Akt/mTOR signaling|||Stem Cells

• Bioactivity:

  Umbralisib (TGR-1202) sulfate, an orally active compound, serves as a potent, selective inhibitor targeting both PI3K? and casein kinase-1-? (CK1?), with EC50 values of 22.2 nM and 6.0 ?M, respectively. It demonstrates unique immunomodulatory effects on T cells in chronic lymphocytic leukemia (CLL) and is applicable in the research of hematological malignancies.

• Smiles:

  S (=O) (=O) (O) O.NC1=C2C (=NN ([C@@H] (C) C3=C (C (=O) C=4C (O3) =CC=C (F) C4) C5=CC (F) =CC=C5) C2=NC=N1) C6=CC (F) =C (OC (C) C) C=C6

• Molecular Formula:

  C31H26F3N5O7S

• Molecular Weight:

  669.63

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1532533-75-7