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Umbralisib tosylate

CAT: 0931-T72465-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T72465-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1532533-72-4
Target
Casein Kinase, Others, PI3K
Related Pathways
Stem Cells, Others, PI3K/Akt/mTOR signaling, Metabolism
Bioactivity
Umbralisib Tosylate (TGR-1202) is a potent, selectively dual inhibitor targeting PI3Kδ and casein kinase-1-ε (CK1ε), demonstrating oral activity. With EC50 values of 22.2 nM and 6.0 μM for PI3Kδ and CK1ε respectively, it shows unique immunomodulatory effects on T cells in chronic lymphocytic leukemia (CLL) . This compound is utilized in the research of hematological malignancies.
Smiles
S(=O)(=O)(O)C1=CC=C(C)C=C1.NC1=C2C(=NN([C@@H](C)C3=C(C(=O)C=4C(O3)=CC=C(F)C4)C5=CC(F)=CC=C5)C2=NC=N1)C6=CC(F)=C(OC(C)C)C=C6
Molecular Formula
C38H32F3N5O6S
Molecular Weight
743.75
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

CatalogName
MBS5814848Umbralisib tosylate
HY-12279AUmbralisib (tosylate)
205938Umbralisib
HY-12279BUmbralisib (sulfate)
MBS5814888Umbralisib sulfate
GTR19203006Umbralisib hydrochloride
HY-12279R-01Umbralisib (Standard)
HY-12279C-01Umbralisib (hydrochloride)
MBS5754038Umbralisib R-enantiomer
C13255-01Umbralisib (TGR-1202)

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