Palmatine hydroxide

• Target:

  Others|||Apoptosis|||Indoleamine 2,3-Dioxygenase (IDO) |||IDO|||AChR|||Aurora Kinase|||Parasite|||Antibacterial|||Virus Protease

• Related Pathways:

  Apoptosis|||Neuroscience|||Metabolism|||Others|||Chromatin/Epigenetic|||Cell Cycle/Checkpoint|||Microbiology/Virology

• Bioactivity:

  Palmatine hydroxide is an orally active, irreversible inhibitor of indoleamine 2,3-dioxygenase 1 (IDO-1), demonstrating IC50 values of 3 ?M for HEK 293-hIDO-1 and 157?M for rhIDO-1. Additionally, it uncompetitively inhibits the West Nile virus (WNV) NS2B-NS3 protease with an IC50 of 96 ?M. This compound exhibits a range of biological activities, including anti-cancer, anti-oxidation, anti-inflammatory, neuroprotective, antibacterial, and antiviral effects.

• Smiles:

  [OH-].O (C=1C=CC2=CC=3C4=CC (OC) =C (OC) C=C4CC[N+]3C=C2C1OC) C

• Molecular Formula:

  C21H23NO5

• Molecular Weight:

  369.41

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  131-04-4