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LI-2242

CAT: 0931-T72034-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T72034-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2762762-17-2
Target
Others
Related Pathways
Others
Bioactivity
LI-2242 is a potent inositol hexakisphosphate kinase (IP6K) inhibitor with IC50s of 31 nM, 42 nM, 8.7 nM, and 1944 nM for IP6K1, IP6K2, IP6K3, and IPMK, respectively.LI-2242 ameliorated hepatic steatosis by reducing the expression of genes that enhance lipid uptake, lipid stabilization, and adipogenesis, and enhanced mitochondrial oxygen consumption rate (OCR) and insulin signaling in adipocytes and hepatocytes in vitro. LI-2242 ameliorated diet-induced obesity, hyperglycemia and hepatic steatosis in mice.LI-2242 can be used to study type II diabetes, obesity, metabolic complications, venous thrombosis and psychiatric disorders.
Smiles
O=C(O)C1=CC=C2NC(=O)C3(C2=C1)CCN(CC4=CC=C(Cl)C=C4Cl)CC3
Molecular Formula
C20H18Cl2N2O3
Molecular Weight
405.27
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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