LI-2242

• Description:

  LI-2242 is an inositol hexakisphosphate kinase (IP6K) inhibitor. LI-2242 has inhibition effect for IP6K1, IP6K2, IP6K3 and IPMK with IC50 values of 31 nM, 42 nM, 8.7 nM and 1944 nM, respectively. LI-2242 can be used for thew research of type II diabetes, obesity, metabolic complications, venous thrombosis, and psychiatric disorders[1].

• UNSPSC:

  12352005

• Target:

  IPK Superfamily

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease; PI3K/Akt/mTOR

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/li-2242.html

• Purity:

  98.95

• Solubility:

  DMSO : 200 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=CC=C2NC(C3(CCN(CC3)CC4=CC=C(C=C4Cl)Cl)C2=C1)=O)O

• Molecular Formula:

  C20H18Cl2N2O3

• Molecular Weight:

  405.27

• References & Citations:

  [1]Liao G, et al. Identification of Small-Molecule Inhibitors of Human Inositol Hexakisphosphate Kinases by High-Throughput Screening. ACS Pharmacol Transl Sci. 2021;4 (2) :780-789. Published 2021 Mar 3.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2762762-17-2]