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LI-633

CAT: 0013-GTR19274694-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274694-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LI-633 is a selective orally bioactive GABAA receptor positive allosteric modulator (PAM) with a Ki value of 21 nM. It significantly enhances GABA-induced inward currents, with EC50 values ranging from 8 nM (α5β2γ2) to 128 nM (α3β2γ2) . LI-633 also increases muscimol-induced GABAergic currents in rat dorsal root ganglion (DRG) neurons, with an EC50 of 70.4 nM. LI-633 is useful for studying visceral pain.
CAS Number
1849624-82-3
Smiles
O=C (O) C=1N=C2N (C1) C=3C=CC (Cl) =CC3C (=NC2) C=4C=CC=CC4F
Molecular Formula
C18H11ClFN3O2
Molecular Weight
355.75
Storage Conditions
-20°C
Notes
For research use only.

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