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SGK1 inhibitor

CAT: 0931-T71947-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T71947-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1426214-51-8
Target
Others, SGK
Related Pathways
Others, Metabolism
Bioactivity
SGK1 inhibitor is an inhibitor of serum- and glucocorticoid-regulated kinase 1 (SGK1) and SGK2. It is selective for SGK1 and SGK2 over SGK3 in the presence of a high concentration of ATP. SGK1 inhibitor prevents phosphorylation of GSK3β in U2OS cells and decreases cell viability in BYL719-insensitive HCC1954 cells when used in combination with the PI3Kα inhibitor BYL719. SGK1 inhibitor reduces tumor growth in an HCC1954 mouse xenograft model when administered in combination with BYL719.
Smiles
N(S(=O)(=O)C1=C(Cl)C(Cl)=CC=C1)C2=CC=C(C=3N=C4C(=NC3)C(N)=NN4)C=C2
Molecular Formula
C17H12Cl2N6O2S
Molecular Weight
435.29
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

SGK1 inhibitor
CAS Number1426214-51-8
PubChem CID71536970
IUPAC NameN-[4-(3-amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2,3-dichlorobenzenesulfonamide
Molecular FormulaC17H12Cl2N6O2S
Molecular Weight435.3
XLogP2.9
Topological Polar Surface Area135
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Heavy Atom Count28
Formal Charge0
Complexity642
SMILES
C1=CC(=C(C(=C1)Cl)Cl)S(=O)(=O)NC2=CC=C(C=C2)C3=NC4=NNC(=C4N=C3)N
InChI
InChI=1S/C17H12Cl2N6O2S/c18-11-2-1-3-13(14(11)19)28(26,27)25-10-6-4-9(5-7-10)12-8-21-15-16(20)23-24-17(15)22-12/h1-8,25H,(H3,20,22,23,24)
InChIKey
MBNNXCKHRKSGSU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of SGK1 inhibitor
CAS: 1426214-51-8
CID: 71536970
Formula: C17H12Cl2N6O2S
MW: 435.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight435.3
XLogP32.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass434.0119502
Monoisotopic Mass434.0119502
Topological Polar Surface Area135 Ų
Heavy Atom Count28
Formal Charge0
Complexity642
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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