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CP21

CAT: 0931-T71870-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T71870-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
30652-12-1
Target
Others
Related Pathways
Others
Bioactivity
CP21 is an iron chelator that binds to iron in a 3:1 (ligand:iron) ratio. It is active against P. falciparum when used at concentrations of 10 and 100 μM. CP21 inhibits production of prostaglandin I2 induced by epinephrine, arachidonic acid, or A23187 in isolated rat aortic rings with IC50 values of 1.3, 1.3, and 1.4 mM, respectively. It inhibits glutamate-induced oxytosis, as well as decreases iodoacetic acid-induced cytotoxicity in an in vitro model of ischemia, in HT22 mouse hippocampal cells (EC50s = 13 and 9.5 μM, respectively) . CP21 (200 mg/kg) increases the excretion of iron, but not copper, zinc, calcium, or magnesium, in rabbits.
Smiles
CCn1ccc(=O)c(O)c1C
Molecular Formula
C8H11NO2
Molecular Weight
153.18
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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