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P27 Analogue CP2

CAT: 0931-TP3718-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TP3718-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
E1/E2/E3 Enzyme
Related Pathways
Ubiquitination
Bioactivity
P27 Analogue CP2 is a macrocyclic peptide inhibitor that targets the SCFSkp2/Cks1 E3 ubiquitin ligase complex (Kd=32 nM) . By preventing the ubiquitination and subsequent degradation of the p27 protein mediated by SCFSkp2/Cks1, it helps restore p27 levels and inhibits cell proliferation. This compound shows potential for research on cancers that rely on Skp2 overexpression, such as breast cancer.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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