LEQ-506

• Target:

  Hedgehog/Smoothened|||Others

• Related Pathways:

  GPCR/G Protein|||Others|||Stem Cells

• Bioactivity:

  LEQ506, also known as NPV-LEQ506, is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Smoothened antagonist LEQ506 selectively binds to the Hedgehog (Hh) -ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway, thereby inhibiting tumor cell growth.

• Smiles:

  C(C=1C2=C(C(=NN1)N3CCN(CC3)C4=CC=C(C(C)(C)O)C=N4)C=CC=C2)C5=CC=CC=C5

• Molecular Formula:

  C27H29N5O

• Molecular Weight:

  439.55

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1057677-92-5