Gemfibrozil-d6

• Target:

  PPAR|||Cytochromes P450

• Related Pathways:

  Metabolism|||DNA Damage/DNA Repair

• Bioactivity:

  Gemfibrozil-d6 is intended for use as an internal standard for the quantification of gemfibrozil by GC- or LC-MS. Gemfibrozil is a peroxisome proliferator-activated reporter ? and PPAR? agonist. In vivo, gemfibrozil reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia. Gemfibrozil reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-?B subunit p65 and chemokine (C-C) motif ligand 2 (CCL2) in ApoE-/- mice. Formulations containing gemfibrozil have been used in the treatment of high cholesterol.

• Smiles:

  O(CCCC(C(O)=O)(C([2H])([2H])[2H])C([2H])([2H])[2H])C1=C(C)C=CC(C)=C1

• Molecular Formula:

  C15H16D6O3

• Molecular Weight:

  256.37

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1184986-45-5