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Gemfibrozil-d6

CAT: 0931-T71306-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0931-T71306-01Size:500 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1184986-45-5
Target
PPAR, Cytochromes P450
Related Pathways
Metabolism, DNA Damage/DNA Repair
Bioactivity
Gemfibrozil-d6 is intended for use as an internal standard for the quantification of gemfibrozil by GC- or LC-MS. Gemfibrozil is a peroxisome proliferator-activated reporter α and PPARγ agonist. In vivo, gemfibrozil reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia. Gemfibrozil reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-κB subunit p65 and chemokine (C-C) motif ligand 2 (CCL2) in ApoE-/- mice. Formulations containing gemfibrozil have been used in the treatment of high cholesterol.
Smiles
O(CCCC(C(O)=O)(C([2H])([2H])[2H])C([2H])([2H])[2H])C1=C(C)C=CC(C)=C1
Molecular Formula
C15H16D6O3
Molecular Weight
256.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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