Gemfibrozil

• Target :

  PPAR|||Cytochromes P450|||Adrenergic Receptor

• Related Pathways :

  GPCR/G Protein|||Metabolism|||DNA Damage/DNA Repair|||Neuroscience

• Purity :

  0.999

• Bioactivity :

  Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfibrozil is a fibric acid derivative with hypolipidemic effects. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III) . The reduction in hepatic production of apoC-III result in the subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C) . In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C) .

• Smiles :

  CC1=CC(OCCCC(C)(C)C(O)=O)=C(C)C=C1

• Molecular Formula :

  C15H22O3

• Molecular Weight :

  250.33

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  25812-30-0