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Gemfibrozil-d6-1

CAT: 0804-HY-B0258S1Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B0258S1Size:1 Each
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Description
Gemfibrozil-d6-1 (CI-719-d6-1) is the deuterium labeled Gemfibrozil. Gemfibrozil is an activator of PPAR-α, used as a lipid-lowering agent; Gemfibrozil is also a nonselective inhibitor of several P450 isoforms, with Ki values for CYP2C9, 2C19, 2C8, and 1A2 of 5.8, 24, 69, and 82 μM, respectively[1].
CAS Number
1160569-36-7
Product Name Alternative
CI-719-d6-1
UNSPSC
12352211
Target
Cytochrome P450; Isotope-Labeled Compounds; PPAR
Type
Isotope-Labeled Compounds
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease; Cardiovascular Disease
Smiles
O=C(C(C)(CCCOC1=CC(C([2H])([2H])[2H])=CC=C1C([2H])([2H])[2H])C)O
Molecular Formula
C15H16D6O3
Molecular Weight
256.37
References & Citations
[1]Pahan K, et al. Gemfibrozil, a lipid-lowering drug, inhibits the induction of nitric-oxide synthase in human astrocytes. J Biol Chem. 2002 Nov 29;277 (48) :45984-91. Epub 2002 Sep 18.|[2]Almad A, et al. The PPAR alpha agonist gemfibrozil is an ineffective treatment for spinal cord injured mice. Exp Neurol. 2011 Dec;232 (2) :309-17.|[3]Wang JS, et al. Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes. Drug Metab Dispos. 2002 Dec;30 (12) :1352-6.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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