PBT434 HBr

CAT: 0931-MF-0145423-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0145423-01Size:25 mg
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CAS Number
1232841-78-9
Target
Others
Related Pathways
Others
Bioactivity
PBT434 is a novel, brain-penetrant, small molecule inhibitor of ?-synuclein aggregation. In transgenic animal models of Parkinson disease (A53T) and MSA (PLP-?-Syn), PBT434 reduced ?-synuclein aggregation, preserved neurons and improved motor function. Glial cell inclusions were also reduced in a murine MSA model. PBT434 is thought to act by redistributing reactive iron across membranes, thereby blocking intracellular protein aggregation and oxidative stress. The affinity of PBT434 for iron is greater than that of ?-synuclein but lower than that of iron trafficking proteins, e.g., ferritin.
Smiles
Br.CCNCc1nc2c(O)c(Cl)cc(Cl)c2c(=O)n1C
Molecular Formula
C12H14BrCl2N3O2
Molecular Weight
383.07
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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Alternative Products

CatalogName
HY-120475-01PBT434
HY-120475A-01PBT434 (mesylate)
MBS5814724PBT434 methanesulfonate
MBS5813713PBT434 HBr
HY-120475BPBT434 (free base)

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