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F15845 HBr

CAT: 0931-T68499-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T68499-01Size:25 mg
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CAS Number
866760-23-8
Target
Others
Related Pathways
Others
Bioactivity
F 15845 is a blocker of the persistent sodium current prevents consequences of hypoxia in rat femoral artery. F15845 has been shown to selectively inhibit the persistent sodium current of Nav1.5[1] exerting cardioprotective effects following ischemia. In vitro testing showed minimal effects of F15845 on other important ion channels of the heart, including major Ca2+ and K+ channels.[1] This characteristic is thought to account for the limited effect of F15845 to change other heart parameters such as basal cardiac function, hemodynamic functions and ventricular fibrillation. F15845 was also shown to exert improved effects when the membrane potential was depolarized, [1] by acting on the extracellular side of the channel.
Smiles
N(C[C@@H](CSC1=C(OC)C=CC=C1)C)[C@@H]2COC=3C(SC2)=CC=CC3.Br
Molecular Formula
C20H26BrNO2S2
Molecular Weight
456.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

F-15845
CAS Number866760-23-8
PubChem CID72941926
IUPAC Name(3R)-N-[(2S)-3-(2-methoxyphenyl)sulfanyl-2-methylpropyl]-3,4-dihydro-2H-1,5-benzoxathiepin-3-amine;hydrobromide
Molecular FormulaC20H26BrNO2S2
Molecular Weight456.5
Topological Polar Surface Area81.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Heavy Atom Count26
Formal Charge0
Complexity385
SMILES
C[C@@H](CN[C@@H]1COC2=CC=CC=C2SC1)CSC3=CC=CC=C3OC.Br
InChI
InChI=1S/C20H25NO2S2.BrH/c1-15(13-24-19-9-5-3-7-17(19)22-2)11-21-16-12-23-18-8-4-6-10-20(18)25-14-16;/h3-10,15-16,21H,11-14H2,1-2H3;1H/t15-,16+;/m0./s1
InChIKey
CUWFVJMNULNBTG-IDVLALEDSA-N
Chemical Structure
2D Structure
2D structure of F-15845
CAS: 866760-23-8
CID: 72941926
Formula: C20H26BrNO2S2
MW: 456.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight456.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass455.05883
Monoisotopic Mass455.05883
Topological Polar Surface Area81.1 Ų
Heavy Atom Count26
Formal Charge0
Complexity385
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
GTR19187000-01F15845
MBS5811060F15845 HBr

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