EGFR-IN-120

CAT: 0931-T88976-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T88976-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

EGFR, ERK, Akt, Apoptosis

Related Pathways

PI3K/Akt/mTOR signaling, Angiogenesis, Cytoskeletal Signaling, Apoptosis, JAK/STAT signaling, Tyrosine Kinase/Adaptors, MAPK

Bioactivity

EGFR-IN-120 (Compound 11eg) is an orally effective EGFR inhibitor. It exhibits potency against the EGFR L858R/T790M/C797S mutant with an IC50 of 0.053 μM, and displays weaker activity against EGFRWT, with an IC50 of 1.05 μM. EGFR-IN-120 inhibits the phosphorylation of EGFR as well as key downstream effectors including STAT3, AKT, and Erk. This compound induces cell cycle arrest and apoptosis in cells harboring the EGFR mutation. Additionally, EGFR-IN-120 inhibits the proliferation of NSCLC cells containing the EGFR L858R/T790M/C797S mutation, with an IC50 value of 0.052 μM.

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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HY-161923	EGFR-IN-120
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EGFR-IN-120

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