VT-ME6

CAT: 0931-MF-0145201-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0145201-01Size:25 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
1353880-00-8
Target
Others
Related Pathways
Others
Bioactivity
VT-ME6 is a potent and selective sphingosine kinase 2 inhibitor. VT-ME6, contained a quaternary ammonium group as a warhead and established that a positively charged moiety is necessary for engaging key amino acid residues in the enzyme binding pocket.13,14 This compound is moderately potent (Ki = 8 lM) and displays three-fold selectivity for SphK2 over SphK1. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2) . Intervention of the S1P signaling pathway has attracted significant attention because alteration of S1P levels is linked to several disease states including cancer, fibrosis, and sickle cell disease.
Smiles
[I-].CCCCCCCCc1ccc(cc1)[C@H]1CC[C@@H](CC1)[N+](C)(C)CCC
Molecular Formula
C25H44IN
Molecular Weight
485.54
Shipping Conditions
Cool pack
Storage Temperature
-20°C

Related Products

CatalogName
MF-0144654-01ISP-VT
MF-0138306-01VT-1598
MF-0098408-01VT-105
MF-0146291-01VT-1598 tosylate
MF-0145603-01VT-102 free base

Alternative Products

CatalogName
MBS5813442VT-ME6
M11365-01VT-1161
MBS3603269-01VT-1598
HY-163644-01VT-105
MBS130284-01VT-464
MBS5812761ISP-VT
310478MPM-ACID-300MMX30M-VT/VT/VT-ROLL Pipe Markers for Acids & Bases
310542MPM-ACID-200MMX30M-VT/VT/VT-ROLL Pipe Markers for Acids & Bases
310606MPM-ACID-127MMX30M-VT/VT/VT-ROLL Pipe Markers for Acids & Bases
MBS130283-01VT-464 racemate

Popular Products