Cmpd-A

• Target :

  Others

• Related Pathways :

  Others

• Bioactivity :

  Cmpd-A is a time-dependent CENP-E inhibitor with potent antitumor activity. Cmpd-A inhibits the ATPase activity of the CENP-E motor domain, acting as a time-dependent inhibitor with an ATP-competitive-like behavior. Cmpd-A causes chromosome misalignment on the metaphase plate, leading to prolonged mitotic arrest. Treatment with Cmpd-A induces antiproliferation in multiple cancer cell lines.

• Smiles :

  C(N(CCN(C)C)C1C=2C(S(=O)(=O)C1)=C(C#N)C(C(F)(F)F)=CC2)(=O)C3=C(N4C(=N3)C=CC=C4OC)C5=CC(C)=C(F)C=C5

• Molecular Formula :

  C30H27F4N5O4S

• Molecular Weight :

  629.63

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1446399-26-3