ACT-672125

• Target :

  Others|||CXCR

• Related Pathways :

  Autophagy|||Immunology/Inflammation|||GPCR/G Protein|||Others

• Bioactivity :

  ACT-672125 is a Potent CXCR3 Antagonist with Therapeutic Potential in Autoimmune Diseases. ACT-672125 showed good physicochemical properties and safety profile. In a proof-of-mechanism model of lung inflammation, ACT-672125 inhibited the recruitment of CXCR3 expressing T cells into the inflamed lung in a dose-dependent manner.

• Smiles :

  C(F)(F)(F)C1=NC(=C(S1)N2C[C@@H](C)N(C(CN3C(C)=NC(C)=N3)=O)CC2)C=4NC=5C(N4)=CC=C(C5)C6=NOC(C)=N6

• Molecular Formula :

  C25H25F3N10O2S

• Molecular Weight :

  586.59

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1449367-94-5