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Pidnarulex HCl

CAT: 0931-T69908-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T69908-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2101314-20-7
Target
Others
Related Pathways
Others
Bioactivity
Pidnarulex HCl is the salt form of CX-5461, a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage. CX-5461 selectively inhibits rRNA synthesis by Pol I in the nucleolus, but does not inhibit mRNA synthesis by RNA Polymerase II (Pol II) and does not inhibit DNA replication or protein synthesis. Inhibition of Pol I results in nucleolar stress and release of ribosomal proteins (RP) from the nucleolus. The RP bind to Mdm2 and liberate p53 to orchestrate apoptosis in cancer cells. CX-5461 demonstrates a favorable preclinical profile, potently and selectively kills cancer cells, demonstrates robust in vivo efficacy in multiple models, and has demonstrated oral bioavailability in multiple species.
Smiles
Cl.CN1CCCN(CC1)c1ccc2c(n1)n1c3ccccc3sc1c(C(=O)NCc1cnc(C)cn1)c2=O
Molecular Formula
C27H28ClN7O2S
Molecular Weight
550.08
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Pidnarulex hydrochloride
CAS Number2101314-20-7
PubChem CID131699687
IUPAC Name2-(4-methyl-1,4-diazepan-1-yl)-N-[(5-methylpyrazin-2-yl)methyl]-5-oxo-[1,3]benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxamide;hydrochloride
Molecular FormulaC27H28ClN7O2S
Molecular Weight550.1
Topological Polar Surface Area120
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count4
Heavy Atom Count38
Formal Charge0
Complexity915
SMILES
CC1=CN=C(C=N1)CNC(=O)C2=C3N(C4=CC=CC=C4S3)C5=C(C2=O)C=CC(=N5)N6CCCN(CC6)C.Cl
InChI
InChI=1S/C27H27N7O2S.ClH/c1-17-14-29-18(15-28-17)16-30-26(36)23-24(35)19-8-9-22(33-11-5-10-32(2)12-13-33)31-25(19)34-20-6-3-4-7-21(20)37-27(23)34;/h3-4,6-9,14-15H,5,10-13,16H2,1-2H3,(H,30,36);1H
InChIKey
YCGHUQKYOCALNJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Pidnarulex hydrochloride
CAS: 2101314-20-7
CID: 131699687
Formula: C27H28ClN7O2S
MW: 550.1
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight550.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count4
Exact Mass549.1713720
Monoisotopic Mass549.1713720
Topological Polar Surface Area120 Ų
Heavy Atom Count38
Formal Charge0
Complexity915
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
WGC308129-5mgPidnarulex
GTR19210098-01Pidnarulex HCl
C08778-50mgPidnarulex (CX-5461)
S2684-10mgCX-5461 (Pidnarulex)

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