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Pidnarulex HCl

CAT: 0931-T69908-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T69908-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2101314-20-7
Target
Others
Related Pathways
Others
Bioactivity
Pidnarulex HCl is the salt form of CX-5461, a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage. CX-5461 selectively inhibits rRNA synthesis by Pol I in the nucleolus, but does not inhibit mRNA synthesis by RNA Polymerase II (Pol II) and does not inhibit DNA replication or protein synthesis. Inhibition of Pol I results in nucleolar stress and release of ribosomal proteins (RP) from the nucleolus. The RP bind to Mdm2 and liberate p53 to orchestrate apoptosis in cancer cells. CX-5461 demonstrates a favorable preclinical profile, potently and selectively kills cancer cells, demonstrates robust in vivo efficacy in multiple models, and has demonstrated oral bioavailability in multiple species.
Smiles
Cl.CN1CCCN(CC1)c1ccc2c(n1)n1c3ccccc3sc1c(C(=O)NCc1cnc(C)cn1)c2=O
Molecular Formula
C27H28ClN7O2S
Molecular Weight
550.08
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

CatalogName
WGC308129-5mgPidnarulex
MBS5812452Pidnarulex HCl
C08778-5mgPidnarulex (CX-5461)
S2684-10mgCX-5461 (Pidnarulex)

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