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Pimasertib HCl

CAT: 0931-T71163-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T71163-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1236361-78-6
Target
Others, MEK
Related Pathways
MAPK, Others
Bioactivity
Pimasertib HCl is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. Pimasertib selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types.
Smiles
Cl.OC[C@@H](O)CNC(=O)c1ccncc1Nc1ccc(I)cc1F
Molecular Formula
C15H16ClFIN3O3
Molecular Weight
467.66
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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B1698-25Pimasertib
A5573-10Pimasertib (AS-703026)
MBS384239-01AS703026 (Pimasertib)
MBS5813702Pimasertib HCl
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MBS131302AS703026(Pimasertib)

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