XL-188

• Target :

  Others|||DUB

• Related Pathways :

  Cell Cycle/Checkpoint|||Ubiquitination|||Others|||DNA Damage/DNA Repair

• Bioactivity :

  XL-188 is a highly potent and selective inhibitor of USP7. XL188 inhibited USP7 catalytic domain and full-length enzyme with IC50 values of 193 and 90 nM, respectively. XL188 Promotes USP7-Dependent Loss of HDM2 and Increase of p53 and p21. XL188 represents one of only a small set of mammalian DUB inhibitors with low nanomolar potency and a high degree of selectivity relative to other DUBs

• Smiles :

  O=C1C=2C(=CC(NC(CCN3CCN(C)CC3)=O)=CC2)N=CN1CC4(O)CCN(C(C[C@@H](C)C5=CC=CC=C5)=O)CC4

• Molecular Formula :

  C32H42N6O4

• Molecular Weight :

  574.71

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2305045-76-3