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XL-188

CAT: 0931-T69690-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T69690-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2305045-76-3
Target
Others, DUB
Related Pathways
Cell Cycle/Checkpoint, Ubiquitination, Others, DNA Damage/DNA Repair
Bioactivity
XL-188 is a highly potent and selective inhibitor of USP7. XL188 inhibited USP7 catalytic domain and full-length enzyme with IC50 values of 193 and 90 nM, respectively. XL188 Promotes USP7-Dependent Loss of HDM2 and Increase of p53 and p21. XL188 represents one of only a small set of mammalian DUB inhibitors with low nanomolar potency and a high degree of selectivity relative to other DUBs
Smiles
O=C1C=2C(=CC(NC(CCN3CCN(C)CC3)=O)=CC2)N=CN1CC4(O)CCN(C(C[C@@H](C)C5=CC=CC=C5)=O)CC4
Molecular Formula
C32H42N6O4
Molecular Weight
574.71
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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