ABI-231 HCl

CAT: 0931-T69557-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T69557-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2635953-17-0

Target

Others, Microtubule Associated, Endogenous Metabolite, Apoptosis, Virus Protease

Related Pathways

Cytoskeletal Signaling, Others, Apoptosis, Metabolism, Microbiology/Virology

Bioactivity

ABI-231 is a potent, orally bioavailable tubulin inhibitor that interacts with the colchicine binding site and is currently undergoing clinical trials for prostate cancer. ABI-231, has an average IC50 = 5.2 nM against panels of melanoma and prostate cancer cell lines, is orally bioavailable, and strongly suppress melanoma tumors in vivo. ABI-231 holds great promise as a new generation of orally available tubulin inhibitor.

Smiles

C(=O)(C=1NC(C=2C=3C(NC2)=CC=CC3)=NC1)C4=CC(OC)=C(OC)C(OC)=C4.Cl

Molecular Formula

C21H20ClN3O4

Molecular Weight

413.85

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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