DAP-81

• CAS Number :

  794466-17-4

• Target :

  Others|||PLK

• Related Pathways :

  Cell Cycle/Checkpoint|||Others

• Bioactivity :

  DAP-81 is a diaminopyrimidine derivative that targets PLKs, destabilizing kinetochore microtubules. Other spindle tubules are stabilized, resulting in monopolar mitotic spindles. In vitro, DAP-81 inhibits Plk1 at an IC50 of 0.9 nM. DAP-81 is currently in ongoing preclinical evaluations.

• Smiles :

  C(=O)(C1=C(NC=2C(N(=O)=O)=CN=C(NC3=CC=C(NC(C)=O)C=C3)N2)C=CC=C1)C4=CC=CC=C4

• Molecular Formula :

  C25H20N6O4

• Molecular Weight :

  468.46

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C