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DAP-81

CAT: 0931-T68686-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T68686-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
794466-17-4
Target
Others, PLK
Related Pathways
Cell Cycle/Checkpoint, Others
Bioactivity
DAP-81 is a diaminopyrimidine derivative that targets PLKs, destabilizing kinetochore microtubules. Other spindle tubules are stabilized, resulting in monopolar mitotic spindles. In vitro, DAP-81 inhibits Plk1 at an IC50 of 0.9 nM. DAP-81 is currently in ongoing preclinical evaluations.
Smiles
C(=O)(C1=C(NC=2C(N(=O)=O)=CN=C(NC3=CC=C(NC(C)=O)C=C3)N2)C=CC=C1)C4=CC=CC=C4
Molecular Formula
C25H20N6O4
Molecular Weight
468.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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