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FI-700

CAT: 0931-T68497-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T68497-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
866883-79-6
Target
Others
Related Pathways
Others
Bioactivity
FI-700 is a novel and potent FLT3 inhibitor with promising antileukemia activity. FI-700 showed a potent IC (50) value against FLT3 kinase at 20 nmol/L in an in vitro kinase assay. FI-700 showed selective growth inhibition against mutant FLT3-expressing leukemia cell lines and primary acute myeloid leukemia cells, whereas it did not affect the FLT3 ligand (FL) -driven growth of Wt-FLT3-expressing cells. Oral administration of FI-700 induced the regression of tumors in a s.c. tumor xenograft model and increased the survival of mice in an i.v. transplanted model. Furthermore, FI-700 treatment eradicated FLT3/ITD-expressing leukemia cells, both in the peripheral blood and in the bone marrow. (Source: Clin Cancer Res. 2007 Aug 1;13 (15 Pt 1) :4575-82.)
Smiles
N(CCC)C=1C(C=2OC(CN3CCNCC3)=NN2)=CN=C(NCCC=4C=CN=CC4)N1
Molecular Formula
C21H29N9O
Molecular Weight
423.51
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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