2-MT-63

• Target :

  Others|||Tie-2

• Related Pathways :

  Others|||Tyrosine Kinase/Adaptors

• Bioactivity :

  2-MT 63 is a novel TIE-2 kinase inhibitor that demonstrates unique and improved kinase selectivity compared to other inhibitors known to interact with TIE-2. 2-MT 63 has a good kinase selectivity profile in enzyme assays with >30-fold selectivity (typically much greater) against the tested kinases. Importantly, the profile includes selectivity against other targets of relevance for angiogenesis (KDR, PDGFR, EPHB4) .

• Smiles :

  O(C1=C(C=CC=N1)C=2N=C(NC)N=CN2)C3=CC(C(NC4=C(N(CCCN(C)C)C)C=CC(C(F)(F)F)=C4)=O)=C(F)C=C3

• Molecular Formula :

  C29H30F4N8O2

• Molecular Weight :

  598.59

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  870225-11-9