XL-418

• Target :

  Others

• Related Pathways :

  Others

• Bioactivity :

  XL-418 is a selective, orally active small molecule, targeting protein kinase B (PKB or AKT) and ribosomal protein S6 Kinase (p70S6K), with potential antineoplastic activity. XL418 inhibits the activities of PKB and p70S6K, both acting downstream of phosphoinosotide-3 kinase (PI3K) . These kinases are often upregulated in a variety of cancers. Inhibition of PKB by this agent will induce apoptosis, while inhibition of p70S6K will result in the inhibition of translation within tumor cells.

• Smiles :

  BrC=1C2=C(N=CN=C2NN1)N3CCN(CC3)C4=CC(C(CCC(F)(F)F)=O)=CC(NCCN5CCCC5)=C4C

• Molecular Formula :

  C26H32BrF3N8O

• Molecular Weight :

  609.48

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  871343-09-8