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RWJ-58643 HCl

CAT: 0931-T68474-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T68474-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
287182-52-9
Target
Others, Serine Protease
Related Pathways
Proteases/Proteasome, Others
Bioactivity
RWJ 58643 is a reversible beta-tryptase and trypsin inhibitor. Low-dose RWJ-58643 (100 microg) and budesonide (200 microg) significantly reduced symptoms, eosinophils and levels of IL-5 following NAC. However, higher doses of RWJ-58643 (300 and 600 microg) caused a late eosinophilia and preceding increases in IL-5 compared with placebo.
Smiles
C(C(NC(=O)[C@H]1N(C(C)=O)C[C@H](O)C1)CCCNC(=N)N)(=O)C2=NC=3C(S2)=CC=CC3.Cl
Molecular Formula
C20H27ClN6O4S
Molecular Weight
482.984
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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