RWJ-58643

• CAS Number :

  287183-00-0

• Target :

  Others|||Serine Protease

• Related Pathways :

  Others|||Proteases/Proteasome

• Bioactivity :

  RWJ-58643 is a ?-trypsin and trypsin inhibitor used in studies to inhibit allergic inflammatory conditions. The compound was effective in reducing nasal allergy symptoms, eosinophil infiltration, and interleukin-5 (IL-5) levels at a lower dose (100 mg) . However, at higher doses (300 mg and 600 mg), an increase in eosinophils and elevated IL-5 levels were observed, showing a clear dose-dependent response.

• Smiles :

  C(C(NC(=O)[C@H]1N(C(C)=O)C[C@H](O)C1)CCCNC(=N)N)(=O)C2=NC=3C(S2)=CC=CC3

• Molecular Formula :

  C20H26N6O4S

• Molecular Weight :

  446.52

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C