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KRN383

CAT: 0931-T68346-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T68346-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
919767-02-5
Target
Others, FLT
Related Pathways
Others, Tyrosine Kinase/Adaptors, Angiogenesis
Bioactivity
KRN383 also inhibited the proliferation of the ITD-positive cell lines with IC (50) values of < or =2.9 nM. A single oral administration of 80 mg/kg of KRN383 eradicated ITD-positive xenograft tumors in nude mice and prolonged the survival of SCID mice carrying ITD-positive AML cells. The effectiveness of a single oral dose of KRN383 suggests that it has the potential to be used in a wide variety of clinical regimens, including multicycle and combination therapies.
Smiles
O(C=1C2=C(C=C(O)C(OC)=C2)N=CC1)C3CC=C(NC(N)=O)C=C3
Molecular Formula
C17H17N3O4
Molecular Weight
327.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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