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Epofolate

CAT: 0931-T68232-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T68232-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
958646-17-8
Target
Others, Apoptosis
Related Pathways
Others, Apoptosis
Bioactivity
Epofolate is folate receptor-targeting antimitotic agent with potential antineoplastic activity. Folate receptor-targeted epothilone BMS753493 contains an epothilone moiety linked to a single folate molecule. Mediated through the folate moiety, this agent delivers the antimitotic epothilone component into cells expressing folic acid receptors, frequently upregulated in many types of tumor cells. After ligand-receptor internalization, the epothilone moiety induces microtubule polymerization and stabilizes microtubules against depolymerization, resulting in the inhibition of mitosis and cellular proliferation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) .
Smiles
C(COC(OCCSSC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CC[C@H](NC(=O)C1=CC=C(NCC=2N=C3C(NC2)=NC(N)=NC3=O)C=C1)C(O)=O)=O)CC(O)=O)=O)CCCNC(=N)N)=O)CC(O)=O)=O)C(O)=O)=O)N4[C@@]5([C@]4(CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O[C@H](\C(=C\C=6N=C(C)SC6)\C)C5)[H])[H]
Molecular Formula
C67H92N16O22S3
Molecular Weight
1569.74
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
MBS5810797Epofolate

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