OK-1035

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  OK-1035 is a potent and selective DNA-PK inhibitor. When a synthetic peptide was used as a substrate, OK-1035 caused 50% inhibition of DNA-PK activity at 8 microM. OK-1035 inhibited the phosphorylation by DNA-PK of consensus peptide as well as that of recombinant human wild type-p53. Kinetic studies indicated that OK-1035 inhibited DNA-PK activity in an ATP-competitive manner.

• Smiles:

  C(=NN)C1=C(C=C(C#N)C(=O)N1)C=2C=CN=CC2

• Molecular Formula:

  C12H9N5O

• Molecular Weight:

  239.23

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  98293-88-0