WDR5-0102

• Target:

  JAK|||Histone Methyltransferase

• Related Pathways:

  Chromatin/Epigenetic|||JAK/STAT signaling|||Stem Cells|||Angiogenesis|||Tyrosine Kinase/Adaptors

• Purity:

  0.9803

• Bioactivity:

  WDR5-0102 is a compound that inhibits the WDR5-MLL1 interface (K dis = 7 ?M, K d = 4 ?M), selectively reducing MLL1 HMT activity without affecting the human H3K4 methyltransferase SETD7 or other HMTs, including G9a, EHMT1, SUV39H2, SETD8, PRMT3, and PRMT5.

• Smiles:

  N(C(=O)C1=C(Cl)C=CC=C1)C2=C(C=CC(N(=O)=O)=C2)N3CCN(C)CC3

• Molecular Formula:

  C18H19ClN4O3

• Molecular Weight:

  374.82

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  824960-50-1