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Butyzamide

CAT: 0931-T67894-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T67894-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1110767-45-7
Target
STAT, JAK, p38 MAPK, Thrombopoietin Receptor
Related Pathways
Chromatin/Epigenetic, JAK/STAT signaling, MAPK, Stem Cells, Immunology/Inflammation, Angiogenesis, Tyrosine Kinase/Adaptors
Purity
>99.99%
Bioactivity
Butyzamide is an effective and oral Mpl activator. It is a novel non-peptide-based molecule with antagonistic effects on thrombopoietin (TPO) receptors, which promotes proliferation of human Mpl (hMpl) expression and mouse pro B cell line Ba/F3. The phosphorylation of JAK2, STAT3, STAT5 and MAPK is induced. Butyzamide has been shown to help increase platelet levels in mouse xenotransplantation trials.
Smiles
O(C)C1=C(C=CC=C1C(OCCC)C(C)(C)C)C=2N=C(NC(=O)C3=CC(Cl)=C(/C=C(/C(O)=O)\C)C(Cl)=C3)SC2
Molecular Formula
C29H32Cl2N2O5S
Molecular Weight
591.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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