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DBRD9 HCl

CAT: 0931-T31221L-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T31221L-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2341840-98-8
Target
Epigenetic Reader Domain, PROTACs
Related Pathways
Chromatin/Epigenetic, PROTAC
Purity
0.9981
Bioactivity
DBRD9 HCl is a PROTAC composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide . dBRD9 HCl is a potent and selective degrader of BRD9 (IC50 = 56.6 nM in MOLM-13 cells) . dBRD9 HCl does not degrade BRD4 or BRD7 at concentrations up to 5 μM. dBRD9 HCl displays antiproliferative effects in human AML cell lines.
Smiles
O=C1C2=C(C(C3=CC(OC)=C(CN(CC(NCCOCCOCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C)C(OC)=C3)=CN1C)C=CN=C2.Cl.Cl
Molecular Formula
C40H47Cl2N7O10
Molecular Weight
856.75
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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