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DBRD9 (dihydrochloride)

CAT: 0804-HY-117690ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-117690ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DBRD9 dihydrochloride is a selective BRD9 PROTAC degrader. dBRD9 dihydrochloride inhibits proliferation of AML cell lines[1].
CAS Number
2341840-98-8
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dbrd9-dihydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN(CC4=C(OC)C=C(C(C5=CC=NC=C65)=CN(C)C6=O)C=C4OC)C.Cl.Cl
Molecular Formula
C40H47Cl2N7O10
Molecular Weight
856.75
References & Citations
[1]Remillard D, Buckley DL, Paulk J, Brien GL, Sonnett M, Seo HS, Dastjerdi S, Wühr M, Dhe-Paganon S, Armstrong SA, Bradner JE. Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands. Angew Chem Int Ed Engl. 2017 May 15;56 (21) :5738-5743.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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