αMβ2 integrin agonist-1

• Target:

  Integrin

• Related Pathways:

  Cytoskeletal Signaling

• Bioactivity:

  ?M?2integrinagonist-1 (Compound 8) is a highly selective ?M?2 integrin agonist with anti-inflammatory properties (EC50=1.4 nM) . It activates integrin-mediated cell adhesion and the JNK/ERK signaling pathway. Additionally, ?M?2integrinagonist-1 induces polarization of tumor-associated macrophages and enhances antitumor T-cell immune responses. This compound holds potential for research in cancer and chronic inflammatory diseases such as pancreatic cancer and rheumatoid arthritis.

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C