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MS44

CAT: 0931-T212241-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T212241-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
PROTACs, Aurora Kinase
Related Pathways
Chromatin/Epigenetic, PROTAC, Cell Cycle/Checkpoint
Bioactivity
MS44 is a potent degrader of aurora kinase B (AURKBPROTAC) with a degradation concentration (DC50) of 103 nM. It effectively and selectively degrades AURKB in a time- and ubiquitin-proteasome system (UPS) -dependent manner, showing specificity for AURKB over AURKA and AURKC. MS44 inhibits the proliferation of various cancer cell lines and strongly induces G2/M arrest. It is useful for studying AURKB-dependent tumors.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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