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MS40

CAT: 0931-T202406-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T202406-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2407449-49-2
Bioactivity
MS40 is a WDR5 PROTAC that selectively degrades WDR5 and serves as a novel degrader for immune-modulating compounds (IMiDs), including the new substrates CRBN and Ikaros zinc finger (IKZF) transcription factors IKZF1 and IKZF3. MS40 facilitates the degradation of WDR5, resulting in the dissociation of the MLL/KMT2A complex from chromatin, thereby reducing H3K4me2 levels. In vitro, MS40 inhibits the growth of primary leukemia patient cells, and in vivo, it suppresses the expansion of patient-derived xenografts.
Smiles
O=C1C=C(C(=CN1)C(=O)NC2=CC(=CC=C2N3CCN(C)CC3)C=4C=CC=C(C4)CN5CCN(CCNC(=O)CCCCCCCNC6=CC=CC=7C(=O)N(C(=O)C67)C8C(=O)NC(=O)CC8)CC5)C(F)(F)F
Molecular Formula
C52H61F3N10O7
Molecular Weight
995.1
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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