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MS44

CAT: 0804-HY-175525Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175525Size:1 Each
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Description
MS44 is a potent aurora kinase B (AURKB PROTAC) degrader (DC50 = 103 nM) . MS44 effectively degrades AURKB in a time- and ubiquitin-proteasome system (UPS) -dependent manner and is selective for AURKB over AURKA and AURKC. MS44 effectively inhibits the proliferation in multiple cancer cell lines and potently induces G2/M arrest. MS44 can be used for the study of AURKB-dependent tumors (Pink: Target protein ligand (HY-175526) ; Blue: E3 ligand (HY-112078) ; Black: Linker; E3 ligand + Linker (HY-132938) ) [1].
UNSPSC
12352005
Target
Aurora Kinase; PROTACs
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CC1=C(SC=N1)C2=CC=C(C=C2)[C@@H](NC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCCCCCC(N(CCCOC4=CC5=NC=NC(NC6=NNC(CC(NC7=CC=CC(F)=C7)=O)=C6)=C5C=C4)CCO)=O)=O)=O)O)=O)C
Molecular Formula
C57H72FN11O8S
Molecular Weight
1090.31
References & Citations
[1]Hu X, et al. Discovery of the first-in-class Aurora B kinase selective degrader. Eur J Med Chem. 2025 Nov 15;298:118006.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora B; von Hippel-Lindau (VHL)

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