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CDK6/9-IN-2

CAT: 0013-GTR19264297-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19264297-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDK6/9-IN-2 is a highly potent dual inhibitor of CDK6 (IC50 = 15 nM) and CDK9 (IC50 = 22 nM) with selectivity over CDK2, CDK8, and CDK11. It suppresses proliferation in IFN-γ/TNF-α-induced HaCaT cells and inhibits the STAT3 pathway and expression of inflammatory factors. CDK6/9-IN-2 alleviates psoriasis dermatitis and is applicable in psoriasis research.
CAS Number
3068529-24-5
Field of Research
Cell Biology, Immunology & Inflammation, Signal Transduction, Stem Cell & Developmental Biology
Smiles
O[C@@H]1CN (C2=CC=C (NC3=NC (NC4=CC=C (C=C4) N5CCN (C) CC5) =NC=C3Cl) C=C2) CC1
Molecular Formula
C25H30ClN7O
Molecular Weight
480.01
Storage Conditions
-20°C
Notes
For research use only.

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