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SK2187

CAT: 0931-T211420-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T211420-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3038446-91-9
Target
PROTACs, Aurora Kinase
Related Pathways
PROTAC, Chromatin/Epigenetic, Cell Cycle/Checkpoint
Bioactivity
SK2187 is a selective degrader of AURKAPROTAC with a DC50 of approximately 10 nM. It exhibits growth-inhibitory effects on NGP cells, with an IC50 value of 101.5 nM. SK2187 is utilized in studies of MYCN-amplified neuroblastoma.
Smiles
C([C@@]1(C(NCCOCCOCCOCCNC(COC2=C3C(C(=O)N(C3=O)C4C(=O)NC(=O)CC4)=CC=C2)=O)=O)CC[C@@H](OC5=C(F)C(Cl)=CC=C5)CC1)C=6N=C(NC7=NC=CS7)C=CC6
Molecular Formula
C45H49ClFN7O11S
Molecular Weight
950.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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