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SK2188

CAT: 0931-T210633-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210633-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3038446-94-2
Target
Aurora Kinase, PROTACs, Apoptosis, Caspase
Related Pathways
PROTAC, Apoptosis, Proteases/Proteasome, Cell Cycle/Checkpoint, Chromatin/Epigenetic
Bioactivity
SK2188 is a potent and selective PROTAC degrader targeting AURKA (DC50 = 3.9 nM) . It induces DNA damage and apoptosis (Apoptosis), indirectly degrades MYCN, and inhibits tumor cell proliferation, offering insights for research on MYCN-amplified neuroblastoma.
Smiles
C([C@@]1(C(NCCOCCOCCOCCOC2=C3C(C(=O)N(C3=O)C4C(=O)NC(=O)CC4)=CC=C2)=O)CC[C@@H](OC5=C(F)C(Cl)=CC=C5)CC1)C=6N=C(NC7=NC=CS7)C=CC6
Molecular Formula
C43H46ClFN6O10S
Molecular Weight
893.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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