MT-125

• Target:

  ROS|||PDGFR|||mTOR|||ERK|||Myosin|||Ferroptosis|||Akt

• Related Pathways:

  PI3K/Akt/mTOR signaling|||Apoptosis|||Immunology/Inflammation|||Tyrosine Kinase/Adaptors|||MAPK|||Angiogenesis|||Cytoskeletal Signaling

• Bioactivity:

  MT-125 is a specific and well-tolerated inhibitor of non-muscle myosin IIA [Ki, NMIIA = 2.7 ?M] and IIB [EC50 = 1.7 ?M]. It can cross the blood-brain barrier and induces ferroptosis and DNA damage by raising reactive oxygen species (ROS) levels within tumor cells. Additionally, MT-125 enhances the PDGFR signaling pathway and is utilized in glioblastoma research.

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C