MSN-125

• Target :

  Akt|||Apoptosis|||Bcl-2 Family

• Related Pathways :

  Apoptosis|||PI3K/Akt/mTOR signaling|||Cytoskeletal Signaling

• Bioactivity :

  MSN-125 effectively inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons protect primary neurons against glutamate excitotoxicity. MSN-125 is an effective Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochondrial outer membrane permeabilization (MOMP) (IC50: 4 ?M) .

• Smiles :

  COCCOCOc1ccc2[C@@H]([C@@H](CN)Oc2c1)N(Cc1ccc(Br)cc1)C(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1

• Molecular Formula :

  C36H38BrN3O6

• Molecular Weight :

  688.61

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1592908-16-1