XSJ110

CAT: 0931-T211140-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T211140-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

203923-65-3

Target

Apoptosis, Topoisomerase

Related Pathways

DNA Damage/DNA Repair, Apoptosis

Bioactivity

XSJ110 is a potent irreversible inhibitor of topoisomerase I (Topo I) with an IC50 value of 0.133 μM. It halts the topoisomerization process of DNA, leading to double-strand breaks and inducing cell cycle arrest in the G0/G1 phase, ultimately causing apoptosis in tumor cells. XSJ110 shows potential for research in ampullary carcinoma (AC) .

Smiles

C(CC)(=O)C1=C2C(C=3N(C2)C(=O)C4=C(C3)[C@](CC)(O)C(=O)OC4)=NC=5C1=CC=CC5

Molecular Formula

C23H20N2O5

Molecular Weight

404.42

Shipping Conditions

Ice Packs

Storage Temperature

-20°C