ITK inhibitor

CAT: 0931-MF-0000659-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0000659-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
439574-61-5
Target
Others
Related Pathways
Others
Bioactivity
Interleukin-2-inducible T cell kinase (ITK) is a non-receptor tyrosine kinase expressed in T cells, NKT cells and mast cells which plays a crucial role in regulating the T cell receptor (TCR), CD28, CD2, chemokine receptor CXCR4, and FcepsilonR-mediated signaling pathways. ITK inhibitors can be used for the treatment of inflammation and immune-mediated disorders. ITK inhibitor (N-[5-[[3-[ (4-Acetylpiperazin-1-yl) carbonyl]-4-methyl-6-methoxy-phenyl]thio]thiazol-2-yl]-4- (N-1,2-dimethylpropylaminomethyl) benzamide) is the analogue of BMS-509744, which can potently and selectively inhibit Itk kinase activity.
Smiles
C(=O)(C1=C(OC)C=C(C)C(SC=2SC(NC(=O)C3=CC=C(CNC(C(C)C)C)C=C3)=NC2)=C1)N4CCN(C(C)=O)CC4
Molecular Formula
C31H39N5O4S2
Molecular Weight
609.8
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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